Since its appearance, the N.C.E.F. [NEW CELLULAR ENCAPSULATED FACTORS] quickly established itself as the star ingredient complex in our laboratories. Integrated into all our treatments⁽¹⁾, this technology is the result of the know-how and research of our experts, inspired by injections performed in aesthetic medicine.
In this article, we review its history, its formulation, and the scientific evidence that makes the NCEF the DNA of FILORGA's anti-aging performance.
The essentials of the NCEF in a few lines
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The N.C.E.F. is a complex directly inspired by mesotherapy injections developed by Dr. Michel Tordjman.
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Its formula has been refocused around ten active ingredients essential to cellular metabolism, in optimized concentrations to ensure maximum effectiveness.
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Thanks to an exclusive encapsulation technology, these active ingredients penetrate the skin to act deep within it.
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Clinical studies have demonstrated visible results after 7 days, with an improvement in skin tone evenness, firmness, and a significant reduction in wrinkles. in 28 days.
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Combining NCEF-REVITALIZE Serum with a mesotherapy injection protocol amplifies, complements, and extends the results over time.
The History of NCEF
Dr. Michel Tordjman, a passionate physician and biologist, was convinced in the 1970s that improving skin quality through cellular revitalization was essential to achieve beautiful, younger-looking skin over time. He thus developed an injectable polyrevitalizing solution, which is still an international reference in aesthetic mesotherapy for skin revitalization. auto;">
SKIN QUALITY ACCORDING TO FILORGA This is what we see and feel every day: a radiant and even complexion, visibly hydrated, supple, and toned skin, with a smooth texture and reduced wrinkles. It is the expression of healthy skin, radiating vitality and displaying a youthful, rested appearance. Dedicated to providing daily support to their patients at home, Filorga Laboratories have encapsulated this science of mesotherapy in facial treatments using a unique technology: N.C.E.F. This complex is exclusive to Filorga and helps revitalize the skin deeply* while improving its quality. Thanks to cutting-edge encapsulation technology, the essential active ingredients of N.C.E.F. used in mesotherapy injections [hyaluronic acid, amino acids, vitamins, coenzyme, minerals, antioxidant] are optimally diffused into the skin to promote the natural production of collagen and elastin. Let's take a closer look at the composition of the N.C.E.F complex. : Naturally present in the human body, hyaluronic acid is particularly abundant in the skin and joints. Its special structure allows it to retain water, giving it hydrating and volumizing properties. The N.C.E.F. incorporates a low molecular weight hyaluronic acid which, thanks to its small size, easily penetrates the skin's layers. It retains water for a moisturizing effect. This active ingredient also has regenerative properties and the ability to boost the natural production of hyaluronic acid and collagen. Our hyaluronic acid is of natural origin, obtained by biofermentation from wheat bran. Amino acids are the building blocks that, once assembled, constitute proteins, which we need for almost all our vital functions. In the skin, for example, they are important components of collagen and elastin. With age, or if we don't eat enough protein, protein synthesis, and therefore collagen and elastin, becomes less efficient. This is why N.C.E.F. provides amino acids directly to where they will benefit the skin. Our formula includes: To optimally function, the skin needs protection. The N.C.E.F. therefore includes ergothioneine, one of the most powerful antioxidants, to protect the skin from free radicals and oxidative stress generated by external aggressions and the sun's UV rays.
These micronutrients fulfill multiple functions in the body, from aiding in chemical reactions and enzymatic processes, to the transmission of nerve signals and the regulation of water balance. The N.C.E.F. contains: These essential compounds are needed in small amountsto maintain good health and normal body function. We use two vitamins in the N.C.E.F. : Coenzymes are molecules that assist enzymes in the body's chemical reactions. The N.C.E.F. incorporates NAD (Nicotinamide Adenine Dinucleotide) for its central role in energy production, detoxification, antioxidant regeneration, and cell regulation.
Mesotherapy relies on injecting active substances directly into the skin to stimulate fibroblasts, the key cells for youthful skin. To reproduce this effect in cosmetics, FILORGA experts use a cutting-edge encapsulation technique: the active ingredients are contained in multi-lamellar liposomes, inspired by cell membranes, capable of diffusing them deep into the epidermis.
This technology increases the bioavailability of ingredients, improves their stability, and reduces the risk of irritation. It enables targeted, progressive, and long-lasting action, comparable to that of injections. Ex vivo and in vitro tests have quantified the impact of N.C.E.F. on key skin structures. Thus, the length of elastin fibers (which, as its name suggests, is essential for skin elasticity) significantly increases. The same is true for type I collagen, the pillar of firmness, and for loricrin, a major protein in the skin barrier. At the same time, N.C.E.F. stimulates the production of cellular energy and antioxidants. A clinical study has demonstrated the benefits of NCEF-REVITALIZE serum. From the first week, skin firmness improves (+5.6%)⁽²⁾ as does skin tone evenness (+7.6%)⁽³⁾. After 28 days, the results are even clearer: reduction in the surface area of periorbital wrinkles by 9%⁽⁴⁾, increase in radiance by 7.2%⁽⁵⁾, and +12.9% skin homogeneity⁽⁶⁾. These assessments are corroborated by 94% of the women surveyed, whoconsider their skin smoother and more toned⁽⁷⁾. A study also showed that combining NCEF-REVITALIZE Serum with a mesotherapy injection protocol optimizes results on skin firmness and elasticity, with a gain of +52% and +24% after 9 weeks⁽⁸⁾. The action of the N.C.E.F. complex, and therefore this natural stimulation, allows for better skin quality, superior radiance, and, above all, a strengthened skin barrier. The serum then becomesthe ideal partner for aesthetic procedures and recommended by doctors. “Among the products I recommend most after the procedure, it would specifically be N.C.E.F., which helps repair the skin barrier after stimulating it with mesotherapy.” Dr. Marco Gutierrez [Mexico]⁽⁹⁾
The two innovative NCEF-REVITALIZE Serum and Cream treatments, directly inspired by revitalizing meso-injections used in aesthetic medicine, perfectly illustrate the incomparable sensoriality and action of FILORGA's rich in N.C.E.F. Just mentioned for its remarkable effectiveness, theNCEF-REVITALIZE Serum has an ultra-light texture that absorbs quickly into the skin. It can be used morning and evening on the face and neck, after cleansing. Its formula is suitable for sensitive skin and contains 94% ingredients of natural origin. It can be recommended as an alternative or in addition to revitalizing injections. NCEF-REVITALIZE Cream combines N.C.E.F. with firming peptides. This creamy cream leaves a silky, non-greasy finish, suitable for all skin types, including sensitive skin. Its formula also contains 94% natural-origin ingredients and is applied morning and evening to the face and neck, after the serum.
NCEF-REVITALIZE Mask : this infused sheet mask provides an immediate radiance boost and deep hydration, ideal as a treatment or express treatment. The N.C.E.F. complex. is therefore much more than an ingredient: it embodies FILORGA's scientific approach, inherited from aesthetic medicine. Its expert formulation, validated efficacy, and encapsulation technology make it a pillar of anti-aging performance. With the NCEF-REVITALIZE range, FILORGA offers the science of mesotherapy encapsulated in a complete routine to brighten, smooth, and firm. * Upper layers of the epidermis (1) Except cleansers, sheet masks, and TIME-FILLER SHOT 5XP. (2) Cutometer® measurement - 32 volunteers - results after 7 days of twice-daily application of NCEF-REVITALIZE Serum. (3) Clinical scoring evaluation - 32 volunteers - results after 7 days of twice-daily application of NCEF-REVITALIZE Serum. (4) Image analysis - 32 volunteers - results after 28 days of twice-daily application of NCEF-REVITALIZE Serum. (5) Clinical scoring evaluation - 32 volunteers - results after 28 days of twice-daily application of NCEF-REVITALIZE Serum. (6) Clinical scoring evaluation - 32 volunteers - results after 28 days of twice-daily application of NCEF-REVITALIZE Serum. (7) Self-assessment - 32 volunteers - results after 28 days of twice-daily application of NCEF-REVITALIZE Serum. (8) Clinical study comparing two groups of 25 women (Phototype I to IV - Caucasian skin type): one having followed a protocol of 3 revitalizing injections every 3 weeks and the other having used the Filorga NCEF-REVITALIZE serum twice a day. After 9 weeks: improvement in the appearance of the skin comparable between the two groups in terms of radiance, homogeneity and smoothness. (9) Original testimonial in Portuguese - translated into French by an artificial intelligence tool.
A low-molecular-weight hyaluronic acid
Amino acids
An ultra-protective antioxidant
Vitamins
An essential coenzyme
Encapsulation: Cutting-Edge Technology
Evidence of the clinically proven efficacy of the N.C.E.F. complex
In-depth action
Visible effectiveness from the first 7 days and optimal results after 42 days
An essential ally for mesotherapy injections
Focus on the NCEF-REVITALIZE range
NCEF-REVITALIZE Serum
NCEF-REVITALIZE Cream
NCEF-REVITALIZE Mask
